Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, United States.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, United States.
Eur J Pharm Biopharm. 2018 Jul;128:82-90. doi: 10.1016/j.ejpb.2018.04.018. Epub 2018 Apr 19.
miRNAs are promising therapeutic targets or tools for the treatment of numerous diseases, with most prominently, cancer. The inherent capacity of these short nucleic acids to regulate multiple cancer-related pathways simultaneously has prompted strong research on understanding miR functions and their potential use for therapeutic purposes. A key determinant of miR therapeutics' potential for treatment is their delivery. Viral and non-viral vectors attempt to address the major limitations associated with miR delivery, but several hurdles have been identified. Here, we present an overview on the general limitations of miR delivery, and the delivery strategies exploited to overcome them. We provide an introduction on the advantages and disadvantages of viral and non-viral vectors, and we go into detail to analyze the most prominently used non-viral systems. We provide with an update on the most recent research on this topic and we describe the mechanism and limitations of the lipid-, polymer- and inorganic material- based miR delivery systems.
miRNAs 是治疗多种疾病（尤其是癌症）的有前途的治疗靶点或工具。这些短核酸具有同时调节多个癌症相关途径的内在能力，这促使人们强烈研究 miR 的功能及其在治疗中的潜在用途。miR 治疗的潜在治疗性的一个关键决定因素是它们的递送。病毒和非病毒载体试图解决与 miR 递送相关的主要限制，但已经确定了几个障碍。在这里，我们概述了 miR 递送的一般限制，以及为克服这些限制而采用的递送策略。我们介绍了病毒和非病毒载体的优缺点，并详细分析了最常用的非病毒系统。我们提供了该主题的最新研究的最新信息，并描述了基于脂质、聚合物和无机材料的 miR 递送系统的机制和局限性。
