Floyd Desiree, Purow Benjamin
Neurology Department, University of Virginia, Charlottesville, Virginia (D.F. and B.P.).
Neuro Oncol. 2014 May;16(5):622-7. doi: 10.1093/neuonc/nou049. Epub 2014 Apr 10.
MicroRNAs are small noncoding RNAs encoded in eukaryotic genomes that have been found to play critical roles in most biological processes, including cancer. This is true for glioblastoma, the most common and lethal primary brain tumor, for which microRNAs have been shown to strongly influence cell viability, stem cell characteristics, invasiveness, angiogenesis, metabolism, and immune evasion. Developing microRNAs as prognostic markers or as therapeutic agents is showing increasing promise and has potential to reach the clinic in the next several years. This succinct review summarizes current progress and future directions in this exciting and steadily expanding field.
微小RNA是真核生物基因组中编码的小非编码RNA，已发现其在包括癌症在内的大多数生物学过程中发挥关键作用。胶质母细胞瘤是最常见且致命的原发性脑肿瘤，情况亦是如此，微小RNA已被证明对其细胞活力、干细胞特性、侵袭性、血管生成、代谢和免疫逃逸有强烈影响。将微小RNA开发为预后标志物或治疗剂显示出越来越大的前景，并且有可能在未来几年进入临床。这篇简要综述总结了这个令人兴奋且不断发展的领域的当前进展和未来方向。
