脑缺血性卒中中的 CD4+FoxP3+调节性 T 细胞。
CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke.
机构信息
Neuroimmunology Research, R&D-31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA.
出版信息
Metab Brain Dis. 2011 Mar;26(1):87-90. doi: 10.1007/s11011-010-9226-6. Epub 2010 Nov 17.
Abstract
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25+Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.
摘要
实验性脑缺血性中风可被炎症性 T 细胞加重，并且伴随着系统性的 CD4+CD25+Foxp3+调节性 T 细胞（Treg）增加。为了确定它们对缺血性脑损伤的影响，在诱导中风之前，在 Foxp3(DTR)小鼠中耗尽 Treg。与最近的《自然医学》报告相反，我们的结果明确表明，Treg 耗竭并不影响中风梗死体积，因此不能将这条调节途径与限制中风损伤联系起来。
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