DeLong Jonathan Howard, Ohashi Sarah Naomi, O'Connor Kevin Charles, Sansing Lauren Hachmann
Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Semin Immunopathol. 2022 Sep;44(5):625-648. doi: 10.1007/s00281-022-00943-7. Epub 2022 Jun 29.
Ischemic stroke generates an immune response that contributes to neuronal loss as well as tissue repair. This is a complex process involving a range of cell types and effector molecules and impacts tissues outside of the CNS. Recent reviews address specific aspects of this response, but several years have passed and important advances have been made since a high-level review has summarized the overall state of the field. The present review examines the initiation of the inflammatory response after ischemic stroke, the complex impacts of leukocytes on patient outcome, and the potential of basic science discoveries to impact the development of therapeutics. The information summarized here is derived from broad PubMed searches and aims to reflect recent research advances in an unbiased manner. We highlight valuable recent discoveries and identify gaps in knowledge that have the potential to advance our understanding of this disease and therapies to improve patient outcomes.
缺血性中风会引发免疫反应，这种反应既会导致神经元损失，也有助于组织修复。这是一个复杂的过程，涉及一系列细胞类型和效应分子，并会影响中枢神经系统以外的组织。近期的综述探讨了这一反应的具体方面，但自一篇高级综述总结该领域的整体状况以来，数年已经过去，取得了重要进展。本综述考察了缺血性中风后炎症反应的启动、白细胞对患者预后的复杂影响，以及基础科学发现对治疗方法开发的潜在影响。此处总结的信息来自广泛的PubMed搜索，旨在以无偏见的方式反映近期的研究进展。我们突出了近期有价值的发现，并确定了知识空白，这些空白有可能推动我们对这种疾病的理解以及改善患者预后的治疗方法的发展。
