Martens Lennart
EMBL Outstation, European Bioinformatics Institute (EBI), Cambridge, UK.
Methods Mol Biol. 2011;694:213-27. doi: 10.1007/978-1-60761-977-2_14.
With the advent of more powerful and sensitive analytical techniques and instruments, the field of mass spectrometry based proteomics has seen a considerable increase in the amount of generated data. Correspondingly, the need to make these data publicly available in centralized online databases has also become more pressing. As a result, several such databases have been created, and steps are currently being taken to integrate these different systems under a single worldwide data-sharing umbrella. This chapter will discuss the importance of such databases and the necessary infrastructure that these databases require for efficient operation. Furthermore, the various kinds of information that proteomics databases can store will be described, along with the different types of databases that are available today. Finally, a selection of prominent repositories will be described in more detail, together with the international ProteomExchange consortium that is aimed at uniting all the different databases in a global data sharing collaboration.
随着更强大、更灵敏的分析技术和仪器的出现，基于质谱的蛋白质组学领域所产生的数据量大幅增加。相应地，将这些数据在集中式在线数据库中公开的需求也变得更加迫切。因此，已经创建了几个这样的数据库，并且目前正在采取措施将这些不同的系统整合到一个全球数据共享的框架下。本章将讨论此类数据库的重要性以及这些数据库高效运行所需的基础设施。此外，还将描述蛋白质组学数据库可以存储的各种信息，以及当今可用的不同类型的数据库。最后，将更详细地描述一些著名的知识库，以及旨在通过全球数据共享合作将所有不同数据库联合起来的国际蛋白质组交换联盟。
