Department of Neurology, University of Virginia, PO Box 800394, Charlottesville, Virginia 22908, USA.
Muscle Nerve. 2011 Jan;43(1):14-8. doi: 10.1002/mus.21883.
The MG-QOL15 is helpful in informing the clinician about the patient's perception of the extent of and dissatisfaction with myasthenia gravis (MG)-related dysfunction. The aims of this study were to determine the usefulness of the MG-QOL15 for following individuals with MG and to guide clinical researchers who plan to use the MG-QOL15. We assessed sensitivity and specificity for detecting clinical change and evaluated test-retest reliability. Sensitivities and specificities of various cut-points of change in scores are presented. Also presented are means and standard deviations of MG-QOL15 scores for all patients and for subgroups of patients. The test-retest reliability coefficient was 98.6%. The MG-QOL15 has an acceptable longitudinal construct validity. We consider this instrument to be most useful for informing the clinician about the patient's perception and tolerance of MG-related dysfunction. More objective measures, such as the MG Composite, should also be used to follow disease severity.
MG-QOL15 有助于向临床医生告知患者对肌无力（MG）相关功能障碍的程度和不满的感知。本研究的目的是确定 MG-QOL15 用于随访 MG 患者的有用性，并为计划使用 MG-QOL15 的临床研究人员提供指导。我们评估了检测临床变化的敏感性和特异性，并评估了测试-重测可靠性。呈现了各种变化分数的敏感性和特异性的各种切点。还呈现了所有患者和患者亚组的 MG-QOL15 分数的平均值和标准差。测试-重测可靠性系数为 98.6%。MG-QOL15 具有可接受的纵向构建效度。我们认为该工具对于向临床医生告知患者对 MG 相关功能障碍的感知和耐受性最有用。还应使用更客观的措施，如 MG 综合评分，来跟踪疾病的严重程度。
