15项重症肌无力生活质量问卷意大利语版本的验证

Validation of the italian version of the 15-item Myasthenia Gravis Quality-of-Life questionnaire.

作者信息

Raggi Alberto, Leonardi Matilde, Ayadi Roberta, Antozzi Carlo, Maggi Lorenzo, Baggi Fulvio, Mantegazza Renato

机构信息

Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy.

Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.

出版信息

Muscle Nerve. 2017 Oct;56(4):716-720. doi: 10.1002/mus.25545. Epub 2017 Apr 27.

DOI:10.1002/mus.25545

PMID:28029697

Abstract

INTRODUCTION

In this study we assess the Italian version of the 15-item Myasthenia Gravis Quality-of-Life questionnaire (MG-QOL15).

METHODS

The validation protocol included the MG-QOL15, the 36-item Short Form (SF-36), the Besta Neurological Institute Rating Scale for Myasthenia Gravis, and the MG-Composite. We used the Cronbach α to test reliability, the Spearman correlation to test short-term test-retest, the Kruskal-Wallis test to assess differences in MG-QOL15 between patients with different disease severity, and the Wilcoxon signed-rank test to assess sensitivity to change.

RESULTS

Seventy-two patients were enrolled in the study. The mean MG-QOL15 score was 15.2 ± 12.2, with α = 0.93 and test-retest correlation = 0.93. Compared with the SF-36, the MG-QOL15 was superior in differentiating patients with different MG types (P = 0.041) and severity (P = 0.004), showed higher sensitivity to change (P = 0.003 for improved and P = 0.024 for worsened patients), and had higher correlations with the MG-Composite (rho = 0.367 vs. -0.213 and -0.154).

CONCLUSION

The Italian version of the MG-QOL15 is valid, reliable, stable, and sensitive to changes. Muscle Nerve 56: 716-720, 2017.

摘要

引言

在本研究中，我们评估了15项重症肌无力生活质量问卷（MG-QOL15）的意大利语版本。

方法

验证方案包括MG-QOL15、36项简短形式健康调查（SF-36）、贝斯塔神经研究所重症肌无力评定量表以及MG综合量表。我们使用Cronbach α系数检验信度，Spearman相关性检验短期重测信度，Kruskal-Wallis检验评估不同疾病严重程度患者之间MG-QOL15的差异，以及Wilcoxon符号秩检验评估对变化的敏感性。

结果

72例患者纳入本研究。MG-QOL15平均得分为15.2±12.2，α系数=0.93，重测相关性=0.93。与SF-36相比，MG-QOL15在区分不同MG类型（P=0.041）和严重程度（P=0.004）的患者方面更具优势，对变化表现出更高的敏感性（改善患者P=0.003，恶化患者P=0.024），并且与MG综合量表具有更高的相关性（rho=0.367，对比-0.213和-0.154）。