5-羟阿洛因 A 的全合成方法。
Approach toward the total synthesis of 5-hydroxyaloin A.
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
出版信息
Org Lett. 2010 Dec 17;12(24):5632-5. doi: 10.1021/ol102318k. Epub 2010 Nov 17.
Abstract
The synthesis of a thiomethyl analogue of 5-hydroxyaloin A has been achieved using benzyne and naphthyne [4 + 2] cycloadditions with substituted furans. A regiocontrolled cycloaddition was achieved using a silicon tether, and a regioselective ring opening was accomplished using a sulfide as a directing group.
摘要
已经使用苯炔和萘并[4 + 2]环加成反应，以及取代的呋喃，合成了 5-羟基芦荟素 A 的硫甲基类似物。使用硅链来实现区域控制的环加成，并且使用硫化物作为导向基团来实现区域选择性开环。
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