Cordes I, Buchmann S, Scheffner D
Neuropädiatrische Abteilung, Universitäts-Kinderklinik, FU Berlin.
Monatsschr Kinderheilkd. 1990 Feb;138(2):85-7.
A nine year old boy had been treated with valproic acid during one and a half years because of a grand mal epilepsy. Under an additional medication with erythromycin succinate syrup this patient developed a deficiency of prothrombin-complex, which was reversible immediately after oral intake of vitamin K. In this case it is assumed that the simultaneous application of both valproic acid and erythromycin succinate seems to suppress the vitamin K producing intestinal tract bacteria, which has not been reported in the literature so far.
一名9岁男孩因全身性癫痫接受丙戊酸治疗已达一年半。在加用琥珀酸红霉素糖浆治疗后，该患者出现凝血酶原复合物缺乏，口服维生素K后立即恢复正常。在这种情况下，推测丙戊酸和琥珀酸红霉素同时应用似乎抑制了肠道内产生维生素K的细菌，这在目前的文献中尚未见报道。
