Chen Lili, Yang Shaomin, Li Jingyun, Li Jianjian, Liu Yongjian, Wang Zheng, Yang Bihui, Li Tianyi, Li Hanping, Bao Zuoyi, Zhuang Daomin, Liu Siyang, Li Lin
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, China.
AIDS Res Hum Retroviruses. 2011 Jun;27(6):693-9. doi: 10.1089/aid.2010.0264. Epub 2011 Jan 5.
Yunnan province was considered the HIV-1 epicenter of China, where many subtypes and CRFs of HIV-1 were circulating. CRF07_BC and CRF08_BC were two of the main circulating subtypes that caused more than 90% of the HIV-1 infections in intravenous drug users (IDUs) in this district. The cocirculation of these two CRFs in the same area and population predicted the emergence of new second-generation recombinants. This study presented a near full-length genomic analysis of a novel HIV-1 recombination (09YN072) involving CRF07_BC and CRF08_BC. The analyses of the sequence of 09YN072 showed that two CRF07_BC segments were inserted into the CRF08_BC backbone. The discovery of the novel recombinant strain complicates the HIV-1 epidemic in Yunnan, China, as well as the development of effective vaccines to limit the spread of HIV-1 in China.
云南省曾被视为中国的HIV-1流行中心，有许多HIV-1亚型和CRF在该地区传播。CRF07_BC和CRF08_BC是两种主要的流行亚型，在该地区静脉吸毒者（IDU）中导致了90%以上的HIV-1感染。这两种CRF在同一地区和人群中的共同传播预示着新的第二代重组体的出现。本研究对一种涉及CRF07_BC和CRF08_BC的新型HIV-1重组体（09YN072）进行了近全长基因组分析。对09YN072序列的分析表明，两个CRF07_BC片段插入到CRF08_BC主干中。这种新型重组毒株的发现使中国云南的HIV-1疫情以及开发有效疫苗以限制HIV-1在中国传播的工作变得更加复杂。
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