中国两种新型HIV-1独特（B/C）重组形式的鉴定与特征分析。
Identification and characterization of two new HIV type 1 Unique (B/C) recombinant forms in China.
作者信息
Liu Yongjian, Li Lin, Yang Shaomin, Bao Zuoyi, Li Hanping, Wang Zheng, Zhuang Daomin, Liu Siyang, Chen Lili, Fan Yishan, Zhong Min, Gao Li, Wang Xiaolin, Li Jingyun
机构信息
Department of HIV/AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
出版信息
AIDS Res Hum Retroviruses. 2011 Apr;27(4):445-51. doi: 10.1089/aid.2010.0212. Epub 2010 Oct 26.
Recombination was most important in the generation of new viral strains and in the increase of HIV diversity. There were more and more new HIV-1 strains. Not only circulating recombinant forms (CRFs) but also unique recombinant forms (URFs) have been reported around the world. CRF07_BC and CRF08_BC were the two predominant CRFs circulated in Yunnan Province, southwest China. In the present study, we identified two new HIV Type 1 unique (B/C) recombinant gorms in Yunnan Province by nucleotide sequencing in two halves of HIV genome. Although the genomic structures of the two B/C recombinants were different from previously identified CRFs (CRF07_BC and CRF08_BC) and URFs in Yunnan Pprovince, they have several common recombination sites with CRF07_BC and CRF08_BC.
重组在新病毒株的产生以及HIV多样性的增加中最为重要。出现了越来越多的新型HIV-1毒株。世界各地不仅报道了流行重组型（CRF），还报道了独特重组型（URF）。CRF07_BC和CRF08_BC是在中国西南部云南省流行的两种主要CRF。在本研究中，我们通过对HIV基因组两半部分进行核苷酸测序，在云南省鉴定出两种新的1型HIV独特（B/C）重组型。尽管这两种B/C重组体的基因组结构与云南省先前鉴定的CRF（CRF07_BC和CRF08_BC）和URF不同，但它们与CRF07_BC和CRF08_BC有几个共同的重组位点。
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