Li Lin, Chen Lili, Yang Shaomin, Liu Yongjian, Li Hanping, Bao Zuoyi, Wang Zheng, Zhuang Daomin, Liu Siyang, Li Jingyun
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Fengtai District, Beijing, China.
AIDS Res Hum Retroviruses. 2010 Jun;26(6):711-6. doi: 10.1089/aid.2010.0001.
Recombination contributes substantially to the genetic diversity of HIV-1, and mosaic strains arise frequently, especially in populations in which multiple subtypes circulate. Yunnan, which borders the "Golden triangle" region of Southeast Asia in the south, was considered as the epicenter of China. B, CRF01_AE, CRF07_BC, and CRF08_BC are all currently involved in the HIV-1 epidemiology in the area, which suggested the possible emergence of a new recombination. This study presented a near full-length genomic analysis of a novel HIV-1 recombination involving B and C. Different from the reported CRF07_BC and CRF08_BC, the new recombination revealed more breakpoints. This is the first report of a novel recombination involving subtype B and C in Yunnan, China. More work is needed to determine the epidemiologic significance of the new recombination.
重组对HIV-1的基因多样性有重大贡献，嵌合毒株频繁出现，尤其是在多种亚型流行的人群中。云南南部与东南亚的“金三角”地区接壤，被认为是中国的疫情中心。B、CRF01_AE、CRF07_BC和CRF08_BC目前都参与了该地区的HIV-1流行病学，这表明可能出现了新的重组。本研究对一种涉及B和C的新型HIV-1重组进行了近全长基因组分析。与报道的CRF07_BC和CRF08_BC不同，这种新的重组显示出更多的断点。这是中国云南首次报道涉及B和C亚型的新型重组。需要开展更多工作来确定这种新重组的流行病学意义。
