School of Pharmaceutical Science, Shandong University, China.
Crit Rev Ther Drug Carrier Syst. 2010;27(5):371-417. doi: 10.1615/critrevtherdrugcarriersyst.v27.i5.10.
Nanotechnology has a profound effect on many areas of scientific research. Having grown exponentially, the focus of nanotechnology has been on therapeutic activity, such as cancer treatment. Lipid-based nanocarriers have attracted increasing scientific and commercial attention in the last few years as alternative carriers for the delivery of anticancer drugs. Lipid-based nanocarriers have played significant roles in the formulation of anticancer drugs to improve therapeutics. Shortcomings frequently encountered with anticancer compounds, such as poor solubility, normal tissue toxicity, poor specificity and stability, as well as the high incidence rate of drug resistance, are expected to be overcome through use of lipid-based nanocarriers. In this review, the advantages and methods of using nanocarriers to improve cancer treatment efficiency will be discussed. In addition, types of lipid-based nanocarriers are presented and hotspots in research are highlighted. It is anticipated that, in the near future, lipid-based nanocarriers will be further improved to deliver cytotoxic anticancer compounds in a more efficient, specific and safe manner.
纳米技术对许多科学研究领域都有深远的影响。随着纳米技术的飞速发展，其研究重点已经转向治疗活性，例如癌症治疗。在过去几年中，基于脂质的纳米载体作为抗癌药物传递的替代载体，引起了越来越多的科学和商业关注。基于脂质的纳米载体在抗癌药物的制剂中发挥了重要作用，以提高治疗效果。预计通过使用基于脂质的纳米载体，可以克服抗癌化合物经常遇到的缺点，例如溶解度差、正常组织毒性、特异性和稳定性差以及耐药性发生率高。在这篇综述中，将讨论使用纳米载体提高癌症治疗效率的优势和方法。此外，还介绍了基于脂质的纳米载体的类型，并突出了研究的热点。预计在不久的将来，基于脂质的纳米载体将进一步改进，以更有效、更特异和更安全的方式传递细胞毒性抗癌化合物。
