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各类脂质体在药物递送系统中的应用。

Application of Various Types of Liposomes in Drug Delivery Systems.

作者信息

Alavi Mehran, Karimi Naser, Safaei Mohsen

机构信息

Department of nanobiotecnology, 67149 Baghabrisham, Razi University, Kermanshah, Iran.

出版信息

Adv Pharm Bull. 2017 Apr;7(1):3-9. doi: 10.15171/apb.2017.002. Epub 2017 Apr 13.

Abstract

Liposomes, due to their various forms, require further exploration. These structures can deliver both hydrophilic and hydrophobic drugs for cancer, antibacterial, antifungal, immunomodulation, diagnostics, ophtalmica, vaccines, enzymes and genetic elements. Preparation of liposomes results in different properties for these systems. In addition, based on preparation methods, liposomes types can be unilamellar, multilamellar and giant unilamellar; however, there are many factors and difficulties that affect the development of liposome drug delivery structure. In the present review, we discuss some problems that impact drug delivery by liposomes. In addition, we discuss a new generation of liposomes, which is utilized for decreasing the limitation of the conventional liposomes.

摘要

脂质体由于其多种形式,需要进一步探索。这些结构可以为癌症、抗菌、抗真菌、免疫调节、诊断、眼科、疫苗、酶和基因元件递送亲水性和疏水性药物。脂质体的制备导致这些系统具有不同的特性。此外,根据制备方法,脂质体类型可以是单层、多层和大单层;然而,有许多因素和困难会影响脂质体药物递送结构的发展。在本综述中,我们讨论了一些影响脂质体药物递送的问题。此外,我们还讨论了新一代脂质体,其用于减少传统脂质体的局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f274/5426731/ac77413a54d0/apb-7-3-g001.jpg

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