Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, Alabama 36849, USA.
Crit Rev Ther Drug Carrier Syst. 2010;27(5):419-59. doi: 10.1615/critrevtherdrugcarriersyst.v27.i5.20.
The delivery of drugs and cosmetic actives to the skin by nanoparticle formulations has a number of advantages over conventional formulations. Nanoparticle formulations offer protection of incorporated active compounds against chemical degradation, more flexibility in modulating the release of the compound, the use of well-tolerated excipients, and feasibility of large scale production. The materials used in the nanoparticle synthesis and formulation can influence product stability, active ingredient properties and delivery to the intended site of action. This review describes the characteristics and application of various polymeric and lipid materials in the preparation of nanoparticles for topical and transdermal drug delivery.
纳米颗粒制剂将药物和化妆品有效成分递送至皮肤具有许多优于传统制剂的优势。纳米颗粒制剂可保护所包含的活性化合物免受化学降解，在调节化合物释放方面具有更大的灵活性，可使用耐受性良好的赋形剂，并具有大规模生产的可行性。纳米颗粒合成和制剂中使用的材料会影响产品稳定性、活性成分性质以及递送至预期作用部位的效果。本文综述了各种聚合物和脂质材料在制备用于经皮和透皮给药的纳米颗粒中的特性和应用。
