Department of Biotechnological Processes, School of Engineering Chemical, University of Campinas-Unicamp, Campinas, 13083-970, Brazil.
Clin Transl Oncol. 2013 Jun;15(6):417-24. doi: 10.1007/s12094-012-0982-0. Epub 2013 Jan 24.
Basal cell carcinomas and squamous cell carcinomas are non-melanoma skin cancers reported to be among the most common malignancies, being responsible for high human morbidity. Conventional chemotherapy applied to these conditions shows non-specific targeting, thus severe adverse side effects are also commonly reported. New therapeutic strategies based on nanoparticulates technology have emerged as alternatives for site specific chemotherapy. Among the different types of nanoparticulates, lipid nanoemulsions and nanoparticles have several advantages for topical delivery of poorly soluble chemotherapeutics. These particles show sustained drug release and protection of loaded drugs from chemical degradation. This technology is promising to enhance the intracellular concentration of drugs and consequently reduce the cytotoxicity of skin chemotherapy.
基底细胞癌和鳞状细胞癌是非黑色素瘤皮肤癌，据报道是最常见的恶性肿瘤之一，导致人类发病率很高。针对这些情况的传统化疗显示出非特异性靶向性，因此也常报告严重的不良反应。基于纳米颗粒技术的新治疗策略已成为特定部位化疗的替代方法。在不同类型的纳米颗粒中，脂质纳米乳液和纳米颗粒具有许多用于局部递送难溶性化疗药物的优势。这些颗粒显示出药物的持续释放，并保护负载药物免受化学降解。该技术有望提高药物的细胞内浓度，从而降低皮肤化疗的细胞毒性。
