Borgheti-Cardoso Lívia Neves, Ângelo Tamara, Gelfuso Guilherme M, Lopez Renata F V, Gratieri Taís
School of Health Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil.
Curr Drug Targets. 2016;17(13):1545-59. doi: 10.2174/1389450116666151019095121.
Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.
在过去几十年里，人们一直在研究局部给药和透皮给药，它在治疗多种疾病、大分子递送和疫苗接种方面具有优势。最大的挑战是克服角质层（SC）屏障。与传统的局部制剂策略相比，纳米/微系统具有稳定性增强、载药量增加、遮盖不良颜色、毒性降低以及活性剂缓释等优点。然而，尚无确凿研究证明此类系统能够以相关治疗量穿透皮肤。物理方法的应用对于增强药物透过角质层渗透以及靶向毛囊具有很大的潜力。本文综述了采用双重方法的特点和可行性，该方法通过应用物理渗透增强方法，实现载药纳米/微系统的局部或透皮给药。
