Oregon Health & Science University, Portland, 97239, USA.
Aliment Pharmacol Ther. 2011 Jan;33(1):33-40. doi: 10.1111/j.1365-2036.2010.04493.x. Epub 2010 Oct 25.
MiraLAX is gaining acceptance as a bowel cleanser for colonoscopy. We hypothesize that MiraLAX/Gatorade is as efficacious for bowel cleansing as Golytely and is more tolerable for patients undergoing screening colonoscopy.
To compare bowel preparation scores of MiraLAX/Gatorade vs. Golytely and examine differences in patient tolerability.
Patients undergoing screening colonoscopy were randomized to 4 L Golytely or 238 g MiraLAX in 64 ounces Golytely and four bisacodyl tablets. Efficacy in bowel cleansing was assessed using the Boston Bowel Preparation Scale (BPPS). Subjects completed a brief survey assessing patient tolerability.
A total of 190 patients were enrolled (85 male, 105 female; mean age 56.9 years, s.d. 6.3); 87 were randomized to MiraLAX, 103 to Golytely. There was no difference in age, gender or timing of colonoscopy between the bowel preparation groups. Golytely's median total BBPS score was significantly higher than that of MiraLAX [9 (IQR 7-9) vs. 8 (IQR 6-9), P = 0.034]. Golytely had a higher rate of an excellent equivalent BBPS score of 8 or 9 than MiraLAX (70% vs. 55%, P = 0.036). There was no difference in patient tolerability (P = 0.857).
Golytely was more efficacious than MiraLAX/Gatorade in bowel cleansing; both preparations were equally tolerated by patients.
米拉拉克（MiraLAX）作为结肠镜检查的肠道清洁剂逐渐被认可。我们假设米拉拉克/佳得乐（Gatorade）在肠道清洁方面与甘油果糖（Golytely）一样有效，并且对于接受筛查性结肠镜检查的患者更具耐受性。
比较米拉拉克/佳得乐与甘油果糖的肠道准备评分，并检查患者耐受性的差异。
接受筛查性结肠镜检查的患者被随机分为 4 升甘油果糖或 238 克米拉拉克加 64 盎司佳得乐和 4 片比沙可啶。使用波士顿肠道准备量表（Boston Bowel Preparation Scale，BPPS）评估肠道清洁的效果。受试者完成了一份简短的调查，评估患者的耐受性。
共纳入 190 例患者（85 例男性，105 例女性；平均年龄 56.9 岁，标准差 6.3）；87 例随机分为米拉拉克组，103 例随机分为甘油果糖组。两组肠道准备的年龄、性别和结肠镜检查时间无差异。甘油果糖的总 BPPS 评分中位数明显高于米拉拉克组[9（IQR 7-9）比 8（IQR 6-9），P=0.034]。甘油果糖的优秀等效 BPPS 评分（8 或 9）比例高于米拉拉克组（70%比 55%，P=0.036）。患者的耐受性无差异（P=0.857）。
在肠道清洁方面，甘油果糖比米拉拉克/佳得乐更有效；两种制剂对患者的耐受性相同。
