Taichung Veterans General Hospital, Taiwan.
Aliment Pharmacol Ther. 2011 Jan;33(1):89-98. doi: 10.1111/j.1365-2036.2010.04502.x. Epub 2010 Nov 2.
Gastro-oesophageal reflux disease (GERD) has been associated with reflux laryngitis.
To investigate the risk factors and the predictors of pharyngeal acid reflux (PAR) in Taiwanese patients with suspected reflux laryngitis.
With referral from ENT physicians, 104 patients with symptoms and signs suggestive of reflux laryngitis completed a validated symptom questionnaire, an upper endoscopy exam and ambulatory 24-h pH tests with three sensors located at the hypopharynx, proximal and distal oesophagus. Patients with one or more episodes of PAR were considered abnormal.
Pharyngeal acid reflux was identified in 17% (18/104) of patients. In multivariate logistic regression analysis, PAR was independently associated with classical reflux symptoms [adjusted odds ratio (aOR) = 3.5, 95% confidence interval (CI): 1.0-12.8], hiatus hernia (aOR = 6.7, 95% CI: 1.5-30.2) and overweight (aOR = 3.4, 95% CI: 1.0-11.0). In predicting PAR, classical reflux symptoms had a sensitivity of 78% and hiatus hernia had a specificity of 95%. With all three factors, the positive predictive value for PAR was 80%. Classical reflux symptoms included heartburn, chest pain, dyspepsia and acid regurgitation.
Classical reflux symptoms, hiatus hernia and overweight are independent risk factors that may predict pharyngeal acid reflux in patients with suspected reflux laryngitis.
胃食管反流病（GERD）与反流性喉炎有关。
调查台湾地区疑似反流性喉炎患者咽酸反流（PAR）的危险因素和预测因素。
通过耳鼻喉科医生转诊，104 例有反流性喉炎症状和体征的患者完成了一份经过验证的症状问卷、上消化道内镜检查和 24 小时 pH 监测，使用三个传感器分别位于下咽、食管近端和远端。有一次或多次 PAR 发作的患者被认为异常。
在 104 例患者中，有 17%（18/104）的患者存在咽酸反流。在多变量逻辑回归分析中，PAR 与典型反流症状[校正比值比（aOR）=3.5，95%置信区间（CI）：1.0-12.8]、食管裂孔疝（aOR=6.7，95%CI：1.5-30.2）和超重（aOR=3.4，95%CI：1.0-11.0）独立相关。在预测 PAR 方面，典型反流症状的敏感性为 78%，食管裂孔疝的特异性为 95%。所有三个因素的阳性预测值为 80%。典型反流症状包括烧心、胸痛、消化不良和胃酸反流。
典型的反流症状、食管裂孔疝和超重是可能预测疑似反流性喉炎患者咽酸反流的独立危险因素。
