Institute of Integrated Micro and Nano Systems, University of Edinburgh, Edinburgh, UK.
J Neuroendocrinol. 2010 Dec;22(12):1290-300. doi: 10.1111/j.1365-2826.2010.02080.x.
A minimalist model of magnocellular vasopressin neurones was developed to examine the hypothesis that their phasic behaviour is the product of intrinsic voltage- and activity-dependent intracellular mechanisms that create a bistable dynamical system. The model can closely match a range of phasic behaviours recorded in vasopressin cells in vivo, as well as reproduce the three archetypal behaviours of vasopressin cells (continuous firing, sparse sporadic firing and phasic firing) by varying one of the fourteen model parameters. In addition, the mean and standard deviation of burst and silence periods can be matched by varying a further two parameters. In the model, the long-term behaviour (phasic characteristics) of cells is largely independent of the short-term behaviour (interspike intervals).
开发了一个简化的大细胞加压素神经元模型，以检验其假设，即它们的脉冲行为是内在电压和活动依赖性细胞内机制的产物，这些机制创建了一个双稳态动力学系统。该模型可以很好地匹配体内加压素细胞记录的一系列脉冲行为，并且通过改变 14 个模型参数中的一个，还可以再现加压素细胞的三种典型行为（连续放电、稀疏散发性放电和脉冲放电）。此外，通过进一步改变两个参数，可以匹配爆发和静止期的平均值和标准偏差。在该模型中，细胞的长期行为（脉冲特征）在很大程度上独立于短期行为（脉冲间隔）。
