Oral Imaging Center, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.
Gerodontology. 2012 Jun;29(2):e200-5. doi: 10.1111/j.1741-2358.2010.00441.x. Epub 2010 Nov 17.
Periodontitis and cognitive impairment or dementia is relatively common among older adults. Few cross-sectional studies and some longitudinal studies have attempted to link oral health with dementia diagnosis or disease pathology but none has investigated the role of inflammation as a potential mediator.
This study was planned to establish a relation of inflammatory mediators between periodontitis and dementia.
Fifty-five patients with severe periodontitis (range 60-69 years), 20 with dementia (10:10 M:F; range 59-69) and 32 healthy controls (range 58-69 years) were selected. The socio-demographic characteristics, physical health, oral health, education status, and medical status were measured. Serum C-reactive protein (CRP), matrix metalloproteinase (MMP)-8, MMP-9, total IGF-I, free IGF-I and TNF-alpha and GCF MMP-8 &MMP-9 were calculated.
There was no significant difference between the three groups in the level of education, age, occupation, BMI, CAD, CHF and diabetes except dentate status. After adjusting for age, significant differences were found between patients and controls with respect to gingival inflammation, dental plaque, bleeding on probing and probing pocket depth. Total counts of WBCs, neutrophils, thrombocytic counts and serum CRP, MMP-8, MMP-9, TNF-alpha levels were significantly higher in dementia and periodontitis patients in contrast to healthy controls, while, RBC counts, total IGF-I and Hb levels were lowered in dementia and periodontitis patients in comparison to healthy controls, although higher in dementia as compared to periodontitis patients.
This study data suggest a relationship of inflammatory mediators between periodontitis and dementia. Further exploration of this is warranted.
牙周炎和认知障碍或痴呆在老年人中较为常见。少数横断面研究和一些纵向研究试图将口腔健康与痴呆症诊断或疾病病理联系起来，但没有研究炎症作为潜在介质的作用。
本研究旨在确定牙周炎和痴呆之间炎症介质的关系。
选择 55 名患有严重牙周炎的患者（年龄 60-69 岁）、20 名痴呆患者（男女比 10:10；年龄 59-69 岁）和 32 名健康对照者（年龄 58-69 岁）。测量社会人口统计学特征、身体健康、口腔健康、教育状况和医疗状况。计算血清 C 反应蛋白（CRP）、基质金属蛋白酶（MMP）-8、MMP-9、总 IGF-I、游离 IGF-I 和 TNF-α以及 GCF MMP-8 和 MMP-9。
除了有牙状态外，三组在教育程度、年龄、职业、BMI、CAD、CHF 和糖尿病方面无显著差异。调整年龄后，患者与对照组在牙龈炎症、牙菌斑、探诊出血和探诊深度方面存在显著差异。白细胞、中性粒细胞、血小板计数和血清 CRP、MMP-8、MMP-9、TNF-α水平在痴呆和牙周炎患者中明显高于健康对照组，而 RBC 计数、总 IGF-I 和 Hb 水平在痴呆和牙周炎患者中低于健康对照组，但在痴呆患者中高于牙周炎患者。
本研究数据表明牙周炎和痴呆之间存在炎症介质的关系。需要进一步探讨。
