Tichý M, Hrncír Z
2nd Department of Medicine, Charles University, Hradec Králové, Czechoslovakia.
Neoplasma. 1990;37(1):55-9.
Concentrations of the light chains kappa and lambda were determined by simple radial immunodiffusion in the blood sera of 437 patients with monoclonal gammopathies. The kappa/lambda index was calculated in monoclonal gammopathies with the antigenic type of kappa light chains, while in monoclonal gammopathies with the antigenic type of lambda light chains the lambda/kappa index was calculated. The results obtained in malignant monoclonal gammopathies were compared with the results obtained in monoclonal gammopathies of undetermined significance for IgG and IgM paraproteinemias. Differences of high statistical significance were established (for IgG and IgA p less than 0.001, for IgM p less than 0.005) and thus the light-chain index can be used as another marker in differential diagnosis of monoclonal gammopathies.
通过简单放射免疫扩散法测定了437例单克隆丙种球蛋白病患者血清中κ和λ轻链的浓度。在具有κ轻链抗原类型的单克隆丙种球蛋白病中计算κ/λ指数，而在具有λ轻链抗原类型的单克隆丙种球蛋白病中计算λ/κ指数。将恶性单克隆丙种球蛋白病的结果与意义未明的单克隆丙种球蛋白病中IgG和IgM副蛋白血症的结果进行比较。确定了具有高度统计学意义的差异（IgG和IgA的p值小于0.001，IgM的p值小于0.005），因此轻链指数可作为单克隆丙种球蛋白病鉴别诊断中的另一个标志物。
