Mattei M G, Simon-Chazottes D, Hirai S, Ryseck R P, Galcheva-Gargova Z, Guénet J L, Mattei J F, Bravo R, Yaniv M
INSERM U242, Hôpital d'enfants de la Timone, Marseille, France.
Oncogene. 1990 Jan;5(1):151-6.
The three members of the jun proto-oncogene family c-jun, jun b and jun D were mapped on the mouse chromosome by in situ hybridization. The c-jun locus is on chromosome 4 subregion C5----C7, whereas jun B and jun D are co-localized on chromosome 8 subregion C. RFLP analysis of interspecific hybrids confirmed the mapping of jun B and D and showed that they are situated about 7.3 +/- 3.5 cM apart. Thus despite their possible origin from a single ancestral gene they are not closely linked on the chromosome. Using the same probes, we showed that the human genome also contains sequences homologous to the mouse jun B and jun D. They are located on human chromosome 19 p13.2, a region that may be involved in chromosomal translocation in acute lymphocytic leukemia (ALL), acute nonlymphocytic leukemia (ANLL) and malignant melanoma (MEL). Finally, the present data identify a new segmental homology between mouse and human chromosomes.
原癌基因家族的三个成员c-jun、jun B和jun D通过原位杂交定位在小鼠染色体上。c-jun基因座位于第4号染色体的C5----C7亚区，而jun B和jun D共定位于第8号染色体的C亚区。种间杂种的RFLP分析证实了jun B和D的定位，并表明它们相距约7.3 +/- 3.5厘摩。因此，尽管它们可能起源于一个单一的祖先基因，但它们在染色体上并不紧密连锁。使用相同的探针，我们发现人类基因组中也含有与小鼠jun B和jun D同源的序列。它们位于人类第19号染色体p13.2区域，该区域可能与急性淋巴细胞白血病（ALL）、急性非淋巴细胞白血病（ANLL）和恶性黑色素瘤（MEL）的染色体易位有关。最后，目前的数据确定了小鼠和人类染色体之间一个新的片段同源性。
