心理社会因素对癌症的影响：不同的早期生活压力经历与乳腺癌的关联。
Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer.
机构信息
Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
出版信息
Cancer Prev Res (Phila). 2010 Nov;3(11):1365-70. doi: 10.1158/1940-6207.CAPR-10-0238. Epub 2010 Nov 7.
Abstract
This perspective on Boyd et al. (beginning on page 1398 in this issue of the journal) discusses recent published research examining the interplay between social stress and breast cancer. Cross-disciplinary studies using genetically defined mouse models and established neonatal and peripubertal paradigms of social stress are illuminating biological programming by diverse early-life experiences for the risk of breast cancer. Understanding the mechanisms underlying this programming can lead to the identification of risk factors and sensitive developmental windows, enabling improved prevention and treatment strategies for this devastating disease.
摘要
这篇关于 Boyd 等人的观点（见本期杂志第 1398 页）讨论了最近发表的研究，这些研究探讨了社会压力与乳腺癌之间的相互作用。使用基因定义的小鼠模型和已建立的新生儿和青春期前社会压力范例进行的跨学科研究，揭示了不同的早期生活经历对乳腺癌风险的生物编程。了解这种编程的机制可以导致确定风险因素和敏感的发育窗口，从而为这种毁灭性疾病提供更好的预防和治疗策略。
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