Ginsberg A, Price S, Ingram D, Nottage E
University Department of Surgery, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
Eur J Cancer. 1996 Nov;32A(12):2049-52. doi: 10.1016/s0959-8049(96)00275-4.
A case-control study was undertaken to investigate the possibility of an association between stressful life events and the development of breast cancer. Ninety-nine breast cancer cases, and 99 controls matched by age and area of residence, completed a life events inventory to measure life change and distress scores over a 2-year and a 10-year period. Study subjects were also interviewed to establish potential breast cancer risk factors; their height and weight were measured; they completed a food frequency questionnaire and provided a fasting blood sample for hormonal assay. After adjusting for potential confounders, women with a 10-year life change score greater than 210 (i.e. the highest quartile) had 4.67 times the risk of developing breast cancer, compared with those in the lowest quartile (P < 0.05).
开展了一项病例对照研究，以调查应激性生活事件与乳腺癌发病之间存在关联的可能性。99例乳腺癌病例以及99名年龄和居住地区匹配的对照者完成了一份生活事件量表，以测量2年和10年期内的生活变化和痛苦得分。还对研究对象进行了访谈，以确定潜在的乳腺癌风险因素；测量了他们的身高和体重；他们完成了一份食物频率问卷，并提供了一份空腹血样用于激素检测。在对潜在混杂因素进行校正后，与处于最低四分位数的女性相比，10年生活变化得分大于210（即最高四分位数）的女性患乳腺癌的风险是其4.67倍（P<0.05）。
