Department of Microbiology, Immunology, and Pathology, Campus Delivery 1619, Colorado State University, Fort Collins, CO 80523-1619, USA.
J Virol. 2011 Feb;85(3):1396-9. doi: 10.1128/JVI.01655-10. Epub 2010 Nov 17.
While chronic wasting disease (CWD) prion transmission, entry, and trafficking remain incompletely elucidated, natural exposure of the oral and/or nasal mucous membranes seems certain. Cervids commonly sustain minor lesions on oral mucous membranes that could have an impact on susceptibility to prion infection. To explore this potential cofactor, we studied cohorts of cervid PrP transgenic mice with or without superficial abrasions on the lingual mucosa to determine whether minor oral mucosa lesions may enhance susceptibility to CWD infections. Results demonstrated that minor lingual abrasions substantially facilitate CWD transmission, revealing a cofactor that may be significant in cervids and perhaps other species.
虽然慢性消耗病（CWD）朊病毒的传播、进入和转运仍不完全清楚，但自然暴露于口腔和/或鼻腔黏膜似乎是肯定的。鹿科动物的口腔黏膜经常会出现轻微损伤，这可能会影响对朊病毒感染的易感性。为了探索这种潜在的协同因素，我们研究了一组有或没有舌黏膜浅表擦伤的鹿科 PrP 转基因小鼠，以确定轻微的口腔黏膜损伤是否会增加对 CWD 感染的易感性。结果表明，轻微的舌黏膜擦伤会显著促进 CWD 的传播，这揭示了一个可能在鹿科动物甚至其他物种中具有重要意义的协同因素。
