Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School, Houston, TX 77030, USA.
Viruses. 2022 Jun 25;14(7):1390. doi: 10.3390/v14071390.
Chronic wasting disease (CWD) is a prion disease affecting several species of captive and free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably, mostly in North America, resulting in a high increase of CWD incidence but also a substantially higher number of geographical regions affected. The massive increase in CWD poses risks at several levels, including contamination of the environment, transmission to animals cohabiting with cervids, and more importantly, a putative transmission to humans. In this review, I will describe the mechanisms and routes responsible for the efficient transmission of CWD, the strain diversity of natural CWD, its spillover and zoonotic potential and strategies to minimize the CWD threat.
慢性消耗病（CWD）是一种影响几种圈养和自由放养鹿科动物的朊病毒病。在过去的几十年中，CWD 一直在不可控制地传播，主要在北美，导致 CWD 的发病率大幅增加，受影响的地理区域也大幅增加。CWD 的大量增加带来了几个层面的风险，包括对环境的污染、与鹿科动物共同生活的动物的传播，更重要的是，可能向人类传播。在这篇综述中，我将描述 CWD 有效传播的机制和途径、天然 CWD 的株多样性、它的溢出和人畜共患病潜力以及最小化 CWD 威胁的策略。
