恶唑酮诱导的胃肠道疾病会增强小鼠中AA淀粉样变性的经口传播。
Oxazolone-induced gastrointestinal disorders enhance the oral transmission of AA amyloidosis in mice.
作者信息
Kobayashi Hiroto, Iwaide Susumu, Ujike Naoki, Murakami Tomoaki
机构信息
Laboratory of Veterinary Toxicology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
出版信息
J Vet Med Sci. 2021 Jun 9;83(6):935-939. doi: 10.1292/jvms.21-0022. Epub 2021 Apr 20.
Amyloid A (AA) amyloidosis is a lethal disease characterized by systemic AA amyloid deposition, and is reported in many animal species. Despite experiments have shown that AA amyloidosis can be transmitted orally, horizontal transmission and cross-species transmission are concerns, the transmission mechanism has been unknown. In this study, we examined the oral transmission efficiency of AA amyloidosis using oxazolone-induced gastrointestinal disorder mice. As a result, the upper or lower gastrointestinal disorder groups developed more severe amyloid deposition in systemic tissues than the group without gastrointestinal disorders. The results of this study suggest that gastrointestinal damage promotes the oral transmission of AA amyloidosis.
淀粉样蛋白A（AA）淀粉样变性是一种以全身性AA淀粉样蛋白沉积为特征的致死性疾病，在许多动物物种中都有报道。尽管实验表明AA淀粉样变性可经口传播，但水平传播和跨物种传播仍令人担忧，其传播机制一直不明。在本研究中，我们使用恶唑酮诱导的胃肠功能紊乱小鼠检测了AA淀粉样变性的经口传播效率。结果显示，与无胃肠功能紊乱的组相比，上消化道或下消化道功能紊乱组在全身组织中出现了更严重的淀粉样蛋白沉积。本研究结果表明，胃肠道损伤促进了AA淀粉样变性的经口传播。
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