Cumberland Foot Health Solutions, Somerset, Kentucky, USA.
Adv Skin Wound Care. 2010 Dec;23(12):544-51. doi: 10.1097/01.ASW.0000391187.89587.2f.
Antimicrobial wound dressings are becoming more popular and are routinely used in the treatment of chronic and problematic wounds. Despite the ever-growing number and types of these antimicrobial products, many practitioners often do not report significant clinical differences between various common antimicrobial wound dressings despite wide variations in cost. Although these dressings use different active ingredients or different presentations of a particular active ingredient, all attempt to protect the wound from bacterial colonization and promote wound repair. With so many topical antimicrobial dressings to choose from in the clinical setting (many having already fallen into disfavor due to their cytotoxic characteristics) it was of prime interest to determine if there was a substantial difference between some of the more commonly used antimicrobial dressings, with silver versus an antimicrobial wound dressing using Oakin (oak extract [Amerx Health Care Corporation, Clearwater, Florida]) as the active ingredient.
This article compares the antimicrobial efficacy of 4 commonly used wound dressings in vitro, utilizing a corrected zone of inhibition test followed by a cost analysis.
In vitro testing demonstrated that there were no substantial differences in the corrected zone of inhibition measurements between the silver wound dressings and the less expensive Oakin-impregnated gauze dressing.
Despite obvious limitations of this study, these results suggest that the biggest differences between many antimicrobial dressings on the market may be more in cost than in antimicrobial efficacy. The differences in cost are due to variances in cost per application and frequency of applications per week.
抗菌伤口敷料越来越受欢迎,常用于治疗慢性和有问题的伤口。尽管这些抗菌产品的数量和种类不断增加,但许多从业者经常报告说,尽管成本差异很大,但各种常见的抗菌伤口敷料之间并没有显著的临床差异。尽管这些敷料使用不同的活性成分或特定活性成分的不同制剂,但它们都试图保护伤口免受细菌定植并促进伤口愈合。在临床环境中有如此多的局部抗菌敷料可供选择(由于其细胞毒性特征,许多已经不受欢迎),因此确定一些更常用的抗菌敷料之间是否存在实质性差异是非常重要的,其中一些敷料使用银,而另一些敷料则使用含有 Oakin(Oak 提取物 [Amerx Health Care Corporation,佛罗里达州克利尔沃特])的抗菌伤口敷料作为活性成分。
本文比较了 4 种常用伤口敷料在体外的抗菌功效,使用校正的抑菌区试验,然后进行成本分析。
体外测试表明,银制伤口敷料和较便宜的 Oakin 浸渍纱布敷料之间的校正抑菌区测量值没有实质性差异。
尽管本研究存在明显的局限性,但这些结果表明,市场上许多抗菌敷料之间的最大差异可能更多体现在成本而非抗菌功效上。成本差异是由于每次应用的成本差异和每周应用的频率差异所致。