320排探测器计算机断层扫描在脑血管狭窄闭塞性疾病患者中的全脑灌注测量：与15O-正电子发射断层扫描的比较
Whole-brain perfusion measurement using 320-detector row computed tomography in patients with cerebrovascular steno-occlusive disease: comparison with 15O-positron emission tomography.
作者信息
Shinohara Yuki, Ibaraki Masanobu, Ohmura Tomomi, Sugawara Shigeki, Toyoshima Hideto, Nakamura Kazuhiro, Kinoshita Fumiko, Kinoshita Toshibumi
机构信息
Department of Radiology, Research Institute of Brain and Blood Vessels - Akita, Senshu-kubota-machi, Akita, Japan.
出版信息
J Comput Assist Tomogr. 2010 Nov-Dec;34(6):830-5. doi: 10.1097/RCT.0b013e3181ebd16a.
OBJECTIVE
The 320-detector row computed tomography (CT) can provide whole-brain CT perfusion (CTP) maps with continuous angiographic images by performing a single dynamic scan. We investigated the reliability of CTP cerebral blood flow (CTP-CBF) with 320-detector row CT by comparing findings with O-positron emission tomography (PET-CBF).
METHODS
Whole-brain CTP and PET were performed in 10 patients with chronic unilateral steno-occlusive disease. We compared absolute and relative CBF values of bilateral middle cerebral artery territories between CTP and PET.
RESULTS
Although mean CTP-CBF values were approximately 30% lower than mean PET-CBF values, the mean ischemic-to-nonischemic CBF ratios of CTP and PET were almost identical (P = 0.804). Regression analysis showed a significant correlation between CTP-CBF and PET-CBF values for each patient (r = 0.52-0.85, P < 0.001).
CONCLUSIONS
Whole-brain CTP using 320-detector row CT is useful for evaluating the degree of ischemia for the entire brain with chronic cerebrovascular disease.
目的
320排探测器计算机断层扫描（CT）通过单次动态扫描能够提供带有连续血管造影图像的全脑CT灌注（CTP）图。我们通过将结果与正电子发射断层扫描（PET-CBF）进行比较，研究了320排探测器CT的CTP脑血流量（CTP-CBF）的可靠性。
方法
对10例慢性单侧狭窄闭塞性疾病患者进行全脑CTP和PET检查。我们比较了CTP和PET双侧大脑中动脉区域的绝对和相对CBF值。
结果
尽管平均CTP-CBF值比平均PET-CBF值低约30%，但CTP和PET的平均缺血与非缺血CBF比值几乎相同（P = 0.804）。回归分析显示每位患者的CTP-CBF和PET-CBF值之间存在显著相关性（r = 0.52 - 0.85，P < 0.001）。
结论
使用320排探测器CT进行全脑CTP有助于评估患有慢性脑血管疾病的整个大脑的缺血程度。
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