McGregor Alexander, Roberts Heidi C, Dong Zhi, Menezes Ravi, Kauczor Hans-Ulrich, Weinheimer Oliver, Heussel Claus Peter
Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
J Comput Assist Tomogr. 2010 Nov-Dec;34(6):933-8. doi: 10.1097/RCT.0b013e3181ef9fbe.
To quantify different emphysema evolution in current and former smokers.
We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile.
The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = -0.257%, P = 0.004; and ΔEVcurrent = -0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers.
We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers.
量化当前吸烟者和既往吸烟者不同的肺气肿演变情况。
我们回顾性分析了一项肺癌筛查研究中59名当前吸烟者和75名既往吸烟者的低剂量计算机断层扫描。使用自制软件（YACTA版本0.9）进行定量肺气肿分析，得出肺容积、肺气肿容积（EV）、肺气肿指数（EI）、平均肺密度和第15百分位数等参数。
基线时的EV和EI存在显著差异（既往吸烟者的EV中位数=422 mL，当前吸烟者的EV中位数=249 mL，P = 0.0003；既往吸烟者的EI中位数=7.6%，当前吸烟者的EI中位数=4.1%，P = 0.0001）。在年度重复扫描中，既往吸烟者的EI和EV中位数显著下降（ΔEI既往吸烟者=-0.257%，P = 0.004；ΔEV当前吸烟者=-0.203 mL，P = 0.020），而当前吸烟者的肺气肿无变化。
我们能够证明当前吸烟者和既往吸烟者的肺气肿演变不同；既往吸烟者的肺气肿参数下降，而当前吸烟者的肺气肿参数保持稳定。
