Glatt A, Klebs K, Koella W P
Biol Psychiatry. 1978 Aug;13(4):417-27.
The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiration. During the experiment, sleep and waking behavior were monitored by the above mentioned telemetrically transmitted indicators and also through observation via closed-circuit television. Both Vincamine and Piracetam in doses of 1 and 300 mg/kg p.o., respectively, enhance absolute and relative amounts of paradoxical sleep (PS). Smaller doses have a lesser or no effect on PS. Larger doses again have little effect or else, in the first few hours after application, reduce PS and total amount of sleep. Both drugs have little effect on slow wave and total sleep. Piracetam, but not Vincamine, reduces the prominent frequency of the theta band in hippocampus during PS. The PS-enhancing effect of the two geriatric drugs may be related to their memory-improving influence.
研究了两种老年药物长春胺和吡拉西坦对实验猫睡眠行为的影响。对动物进行长期准备，以记录大脑皮层、外侧膝状体和海马体的脑电图，以及记录眼动、肌肉张力和呼吸。在实验过程中，通过上述遥测传输指标以及通过闭路电视观察来监测睡眠和清醒行为。长春胺和吡拉西坦分别以1和300mg/kg口服给药剂量，可提高快速眼动睡眠（PS）的绝对量和相对量。较小剂量对PS的影响较小或无影响。较大剂量同样影响较小，或者在给药后的最初几个小时内会减少PS和总睡眠时间。两种药物对慢波睡眠和总睡眠时间影响较小。吡拉西坦而非长春胺可降低PS期间海马体中θ波带的突出频率。这两种老年药物的PS增强作用可能与其改善记忆的影响有关。
