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长春胺对猫睡眠-觉醒平衡的影响(作者译)

[Effect of vincamine on sleep-wakefulness equilibrium in the cat (author's transl)].

作者信息

Da Costa L M, Depoortere H, Naquet R

出版信息

Rev Electroencephalogr Neurophysiol Clin. 1977 Apr-Jun;7(2):158-64. doi: 10.1016/s0370-4475(77)80073-7.

DOI:10.1016/s0370-4475(77)80073-7
PMID:201975
Abstract

Intra-muscular vincamine in the cat (chronic experimental preparation) causes a change in the equilibrium between sleep and wakefulness. This consists of: (1) an increase in the amount of wakefulness, the duration of which depends on the dose injected (5-10 mg/kg) and the mode of injection (more effective when given in two doses than all at once); (2) a decrease in slow wave sleep (SWS) which often has the appearance of phasic slow wave sleep; (3) a transitory suppression of paradoxical sleep (PS). At the time of recovery there is no rebound either of SWS or PS. The mechanism of vinacamine's action is not understood and some interpretations are suggested.

摘要

猫(慢性实验制剂)肌肉注射长春胺会导致睡眠与觉醒平衡的改变。这包括:(1)觉醒量增加,其持续时间取决于注射剂量(5 - 10毫克/千克)和注射方式(分两次给药比一次性给药更有效);(2)慢波睡眠(SWS)减少,且常呈现为相位性慢波睡眠;(3)快速眼动睡眠(PS)的短暂抑制。恢复时,SWS或PS均无反弹。长春胺的作用机制尚不清楚,并提出了一些解释。

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