Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
J Pediatr (Rio J). 2010 Nov-Dec;86(6):509-14. doi: 10.2223/JPED.2043. Epub 2010 Nov 17.
To assess clinical and laboratory parameters and serum cytokine levels in 55 neonates who developed early-onset sepsis.
Clinical parameters associated with early-onset neonatal sepsis were assessed. White blood cell differential and serum C-reactive protein and glucose levels were measured upon diagnosis of sepsis and 48 hours later. IL-beta, IL-10, IL-6, and TNF-α levels were measured in cord blood samples obtained on the day of diagnosis and from samples collected 48 and 96 hours after treatment onset.
Among newborns with early-onset sepsis, the length of hospital stay was inversely correlated with birth weight. Clinical parameters varied widely, especially body temperature. Blood glucose changes - particularly hypoglycemia - were common. Leukopenia, usually due to neutropenia, was the most prevalent change in blood cell count. C-reactive protein levels correlated with the immature-to-total neutrophil ratio. Serum TNF-α and IL-10 levels measured early in the course of sepsis were positively correlated with those detected in cord blood.
Clinical and laboratory parameters varied widely among neonates with sepsis in this sample. In neonates who presented with increased cytokine levels at birth, this abnormality persisted throughout the infectious process.
评估 55 例发生早发性败血症的新生儿的临床和实验室参数及血清细胞因子水平。
评估与早发性新生儿败血症相关的临床参数。在诊断败血症时和 48 小时后测量白细胞分类计数以及血清 C 反应蛋白和葡萄糖水平。在诊断当天以及治疗开始后 48 小时和 96 小时采集脐带血样本，测量 IL-β、IL-10、IL-6 和 TNF-α 水平。
在患有早发性败血症的新生儿中，住院时间与出生体重呈反比。临床参数差异很大，尤其是体温。血糖变化 - 特别是低血糖 - 很常见。白细胞减少症，通常是由于中性粒细胞减少症，是最常见的血细胞计数变化。C 反应蛋白水平与未成熟与总中性粒细胞比值相关。败血症早期测量的血清 TNF-α 和 IL-10 水平与脐带血中检测到的水平呈正相关。
在本样本中，败血症新生儿的临床和实验室参数差异很大。在出生时细胞因子水平升高的新生儿中，这种异常在整个感染过程中持续存在。
