Machado Juliana Reis, Soave Danilo Figueiredo, da Silva Marcos Vinícius, de Menezes Liliana Borges, Etchebehere Renata Margarida, Monteiro Maria Luiza Gonçalves dos Reis, dos Reis Marlene Antônia, Corrêa Rosana Rosa Miranda, Celes Mara Rúbia Nunes
Department of Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goias, 74605-050 Goiania, GO, Brazil ; Department of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, 74605-050 Uberaba, MG, Brazil.
Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049-900 Ribeirao Preto, SP, Brazil.
Mediators Inflamm. 2014;2014:269681. doi: 10.1155/2014/269681. Epub 2014 Dec 30.
Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion.
新生儿败血症是发病和死亡的主要原因，其体征和症状不具有特异性，这使得诊断困难。常规使用的实验室检查并非有效的分析方法，因为它们极不具有特异性，且常常导致抗生素的不恰当使用。败血症是与全身炎症反应相关的感染结果，会产生和释放多种炎症介质。细胞因子是强效的炎症介质，其血清水平在感染期间会升高，因此可能会出现与其他炎症效应分子的变化。尽管促炎和抗炎细胞因子已被确定为新生儿感染的可能标志物，但为了表征败血症期间的炎症反应，有必要分析一组细胞因子，而不仅仅是测量单个细胞因子。炎症介质的测量为新生儿败血症的诊断和随访带来了新的选择，从而能够进行早期治疗，并因此提高新生儿存活率。考虑到新生儿败血症的严重程度，本综述的目的是探讨细胞因子在新生儿败血症发病机制中的作用及其作为诊断标准的价值。
