Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
J Appl Oral Sci. 2010 Sep-Oct;18(5):503-8. doi: 10.1590/s1678-77572010000500013.
The objective of the present study was to verify the hypothesis that no difference in biocompatibility exists between different orthodontic adhesives.
Thirty male Wistar rats were used in this study and divided into five groups (n=6): Group 1 (control, distilled water), Group 2 (Concise), Group 3 (Xeno III), Group 4 (Transbond XT), and Group 5 (Transbond plus Self-Etching Primer). Two cavities were performed in the subcutaneous dorsum of each animal to place a polyvinyl sponge soaked with 2 drops of the respective adhesive in each surgical loci. Two animals of each group were sacrificed after 7, 15, and 30 days, and their tissues were analyzed by using an optical microscope.
At day 7, Groups 3 (Transbond XT) and 4 (Xeno III) showed intense mono- and polymorphonuclear inflammatory infiltrate with no differences between them, whereas Groups 1 (control) and 2 (Concise) showed moderate mononuclear inflammatory infiltrate. At day 15, severe inflammation was observed in Group 3 (Transbond XT) compared to other groups. At day 30, the same group showed a more expressive mononuclear inflammatory infiltrate compared to other groups.
Among the orthodontic adhesive analyzed, it may be concluded that Transbond XT exhibited the worst biocompatibility. However, one cannot interpret the specificity of the data generated in vivo animal models as a human response.
本研究旨在验证以下假设，即不同的正畸粘接剂之间不存在生物相容性差异。
本研究使用 30 只雄性 Wistar 大鼠，将其分为 5 组（n=6）：第 1 组（对照，蒸馏水）、第 2 组（Concise）、第 3 组（Xeno III）、第 4 组（Transbond XT）和第 5 组（Transbond plus Self-Etching Primer）。在每个动物的皮下背部进行两个腔，在每个手术部位放置一个浸泡有 2 滴各自粘接剂的聚维酮海绵。每组各有 2 只动物在第 7、15 和 30 天被处死，对其组织进行光学显微镜分析。
第 7 天，第 3 组（Transbond XT）和第 4 组（Xeno III）表现出强烈的单形核和多形核炎症浸润，且两者之间无差异，而第 1 组（对照）和第 2 组（Concise）表现出中度单核炎症浸润。第 15 天，与其他组相比，第 3 组（Transbond XT）观察到严重的炎症。第 30 天，与其他组相比，同一组表现出更明显的单核炎症浸润。
在所分析的正畸粘接剂中，可以得出结论，Transbond XT 表现出最差的生物相容性。然而，不能将体内动物模型中产生的数据的特异性解释为人类的反应。
