Sokolova R I, Speranskaia N V, Vikhert A M
Biull Eksp Biol Med. 1978 Aug;86(8):150-3.
The content of cyclic nucleotides (cAMP and cGMP) in the blood plasma, urine and tissues, and also morphological changes of the vascular renal bed were studied in rats with arterial hypertension induced by chronic inhibition of prostaglandin synthesis. A considerable thickening of the wall of the interlobular and arcuate arteries with marked lumen narrowing occurred mainly on account of hypertrophy and the swelling of smooth muscle cells. At the same time there was a marked increase in the cGMP concentration, a decrease of cAMP level, and a reduction of the cAMP/cGMP coefficient in the biological fluids. It is suggested that the changed cyclic nucleotides metabolism is associated with organic and functional changes of the peripheral vascular bed underlying an increase of the total vascular resistance in arterial hypertension.
研究了慢性抑制前列腺素合成诱导的动脉高血压大鼠血浆、尿液和组织中循环核苷酸（cAMP和cGMP）的含量，以及肾血管床的形态学变化。小叶间动脉和弓状动脉壁明显增厚，管腔显著狭窄，主要是由于平滑肌细胞肥大和肿胀所致。与此同时，生物体液中cGMP浓度显著升高，cAMP水平降低，cAMP/cGMP系数减小。提示循环核苷酸代谢的改变与动脉高血压时总血管阻力增加所依赖的外周血管床的器质性和功能性变化有关。
