Vikhert A M, Sokolova R I, Nekrasova A A, Kulagina V P, Legen'kaia N P
Kardiologiia. 1979 Dec;19(12):56-61.
It is shown that various types of vessels (elastic, musculo-elastic, and muscular) possess initially different capacity for synthesizing and destroying prostaglandins. Under the effect of indomethacin and salt load considerable changes occur in the synthesis and metabolism of prostaglandins and the closely related system of cyclic nucleotides in the vessels of experimental animals. The character of these changes suggests the predominance of constrictive vascular reactions, which was confirmed by the results of functional tests on segments of the aorta and femoral arteries. It was shown also that the walls of small arteries of different organs, the kidneys in particular, undergo marked structural changes resulting in their thickening and narrowing of the lumen. These functional and structural changes may underlie the increase in peripheral vascular resistance and be the principal pathogenic mechanism of hypertension.
结果表明，不同类型的血管（弹性血管、肌弹性血管和肌性血管）最初合成和破坏前列腺素的能力各不相同。在消炎痛和盐负荷的作用下，实验动物血管中前列腺素的合成与代谢以及与之密切相关的环核苷酸系统发生了相当大的变化。这些变化的特征表明血管收缩反应占主导，这一点在对主动脉和股动脉节段进行的功能测试结果中得到了证实。还发现，不同器官的小动脉壁，尤其是肾脏的小动脉壁，会发生明显的结构变化，导致其增厚和管腔狭窄。这些功能和结构变化可能是外周血管阻力增加的基础，并且是高血压的主要致病机制。
