Institute of Chinese Integrative Medicine, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Mol Biol Rep. 2011 Apr;38(4):2517-28. doi: 10.1007/s11033-010-0389-3. Epub 2010 Nov 18.
β-arrestins are not only well-known negative regulators of G protein-coupled receptor (GPCR) signaling, but also important adaptors in modulating the strength and duration of cellular signaling by scaffolding and interacting with a lot of cytoplasmic proteins. While β-arrestins are rather well described signal-mediated molecules, they are not generally associated with insulin signaling. But recent work has confirmed the difference from original thought. The current review aims to explore the emerging roles for β-arrestins in regulating insulin action, inflammatory signal pathway and other cellular signaling which are associated with type 2 diabetes.
β-arrestins 不仅是 G 蛋白偶联受体 (GPCR) 信号的著名负调节剂，还是通过支架和与许多细胞质蛋白相互作用来调节细胞信号强度和持续时间的重要衔接蛋白。虽然 β-arrestins 是相当成熟的信号转导分子，但它们通常与胰岛素信号无关。但最近的工作证实了与最初想法的不同。本综述旨在探讨β-arrestins 在调节胰岛素作用、炎症信号通路和其他与 2 型糖尿病相关的细胞信号中的新作用。
