Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong.
Int J Geriatr Psychiatry. 2010 Dec;25(12):1272-9. doi: 10.1002/gps.2470.
There is limited data on the effects of alcohol consumption on cognitive impairment in Chinese populations.
To investigate the association between alcohol consumption and the risk of cognitive impairment in Southern Chinese older adults in Hong Kong.
This was a cross-sectional study of 314 Chinese older participants, aged 65 years or over. Participants' socio-demographic, co-morbid diseases, alcohol drinking habits, and Mini Mental State Examination (MMSE) for cognitive function were obtained by a face-to-face interview. Participants were categorized into normal cognitive and cognitively impaired groups by education-adjusted MMSE cut-off scores.
The mean (SD) age of the participants was 79.9 (6.5) years. The average weekly alcohol consumption in the cognitively impaired group was significantly higher than that of the normal cognition group [mean (SD): 861.89 (673.03) versus 241.21 (276.26) grams per week respectively; p < 0.001, t-test]. Drinkers with light to moderate alcohol consumption were associated with higher MMSE scores than non-drinkers and heavy drinkers. Logistic regression analyses showed that heavy drinkers (> 400 g alcohol for men and > 280 g for women) were associated with an increased risk of cognitive impairment (OR = 4.99, 95%CI = 1.8-13.82), while light drinkers and moderated drinkers (< 400 g for men and < 280 g for women) were associated with reduced risks (OR = 0.32, 95%CI = 0.12-0.86; OR = 0.17, 95%CI = 0.06-0.51, respectively). Exercise and age were independent protective and risk factors respectively.
Heavy alcohol consumption is associated with an increased risk of cognitive impairment while light to moderate alcohol consumption is associated with reduced risk among Southern Chinese older adults in Hong Kong.
关于饮酒对中国人认知障碍影响的数据有限。
研究香港南方老年华人中饮酒与认知障碍风险之间的关系。
这是一项对 314 名年龄在 65 岁及以上的华裔老年人进行的横断面研究。通过面对面访谈获得参与者的社会人口统计学、合并症、饮酒习惯以及用于认知功能的简易精神状态检查（MMSE）。根据教育调整后的 MMSE 临界值将参与者分为正常认知和认知障碍组。
参与者的平均（SD）年龄为 79.9（6.5）岁。认知障碍组的每周平均酒精摄入量明显高于正常认知组[平均（SD）：分别为 861.89（673.03）克和 241.21（276.26）克/周；p<0.001，t 检验]。轻度至中度饮酒者的 MMSE 评分高于非饮酒者和重度饮酒者。Logistic 回归分析表明，重度饮酒者（男性>400 克酒精，女性>280 克酒精）与认知障碍风险增加相关（OR=4.99，95%CI=1.8-13.82），而轻度饮酒者和中度饮酒者（男性<400 克，女性<280 克）与风险降低相关（OR=0.32，95%CI=0.12-0.86；OR=0.17，95%CI=0.06-0.51）。运动和年龄分别是独立的保护和风险因素。
重度饮酒与认知障碍风险增加相关，而轻度至中度饮酒与香港南方老年华人认知障碍风险降低相关。
