环氧化酶-2 多态性与胃癌易感性的关系：荟萃分析。
Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis.
机构信息
Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
出版信息
World J Gastroenterol. 2010 Nov 21;16(43):5510-7. doi: 10.3748/wjg.v16.i43.5510.
AIM
To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis.
METHODS
Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was calculated.
RESULTS
Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively).
CONCLUSION
The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.
目的
通过荟萃分析研究环氧化酶-2（COX-2）多态性与胃癌（GC）易感性的关系。
方法
从 MEDLINE、EMBASE 和 CBMdisc 数据库中选择了探讨 COX-2 多态性与 GC 易感性之间关系的研究。由 2 名独立评审员从研究中提取数据。使用 RevMan 5.0.23 进行荟萃分析。根据这些数据，计算了比值比（OR）及其 95％置信区间（CI）。
结果
共检索到 10 项研究，报告了总共 11 个 COX-2 多态性。-765C、-1195A、-1290G、2430T 等位基因和429TT 基因型携带者发生 GC 的风险增加（OR = 1.71，95％CI：1.01-2.90，P = 0.05；OR = 1.58，95％CI：1.05-2.38，P = 0.03；OR = 1.55，95％CI：1.01-2.39，P = 0.05；OR = 2.62，95％CI：1.20-5.73，P = 0.02；OR = 0.74，95％CI：0.59-0.95，P = 0.02）。
结论
COX-2 多态性的-765C、-1195A、-1290G、2430T 等位基因和429TT 基因型与 GC 易感性显著相关。
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