Happonen R P, Bäckström A C, Ylipaavalniemi P
Institute of Dentistry, University of Turku, Finland.
Br J Oral Maxillofac Surg. 1990 Feb;28(1):12-5. doi: 10.1016/0266-4356(90)90003-4.
A clinical double-blind placebo controlled trial was carried out in 136 patients to test the value of the prophylactic use of phenoxymethylpenicillin and tinidazole in mandibular third molar surgery. The three patient groups were uniform with regard to the background data such as age and weight of the patients and the clinical status of the operated tooth, as well as to the observations made at surgery. No statistically significant differences were found between the study groups in the parameters used for evaluation. The results indicate that neither penicillin nor tinidazole have more effect on postoperative complications following operative extraction of wisdom teeth, than placebo tablets.
对136例患者进行了一项临床双盲安慰剂对照试验，以测试在拔除下颌第三磨牙手术中预防性使用青霉素V钾和替硝唑的价值。三组患者在年龄、体重等背景数据、患牙的临床状况以及手术观察方面均保持一致。在用于评估的参数方面，各研究组之间未发现具有统计学意义的差异。结果表明，与安慰剂片相比，青霉素和替硝唑对智齿拔除术后并发症的影响并无差异。
