Tape C, Kisilevsky R
Department of Pathology, Queen's University, Kingston, Canada.
Biochim Biophys Acta. 1990 Apr 17;1043(3):295-300. doi: 10.1016/0005-2760(90)90030-2.
The half-lives of two apolipoproteins of mouse high-density lipoproteins, apo A-I and apo SAA, were determined in normal animals and compared with those having an inflammatory condition, or inflammation leading to AA amyloid deposition. The apo A-I half-life was considerably shorter in animals with inflammation and in those that were preamyloidotic, than in controls (t1/2 of 3-3.5 h vs. 10-12 h). The average loss of apo A-I in controls over the first 10 h was 31.1 micrograms/ml per h, while that in inflamed animals was 58.7 micrograms/ml per h a 2-fold increase in apo A-I clearance. The apo SAA half-life was similar in all groups of animals and was of the order of 1.5 h. The concentration of apo SAA during inflammation is however considerably higher (500-1000-fold) than in controls, which implies a much greater clearance rate during inflammation and involving a process which is apparently not saturable. In addition to hypertriglyceridemia and Tangier's disease, ordinary acute inflammation can now be added to those pathological conditions which lead to a significant decrease in apo A-I half-life.
测定了小鼠高密度脂蛋白的两种载脂蛋白apo A-I和apo SAA在正常动物体内的半衰期，并与患有炎症或炎症导致AA淀粉样蛋白沉积的动物进行了比较。与对照组相比，炎症动物和淀粉样变性前期动物的apo A-I半衰期明显缩短（分别为3 - 3.5小时和10 - 12小时）。对照组在最初10小时内apo A-I的平均损失率为每小时31.1微克/毫升，而炎症动物为每小时58.7微克/毫升，apo A-I清除率增加了2倍。所有动物组中apo SAA的半衰期相似，约为1.5小时。然而，炎症期间apo SAA的浓度比对照组高得多（500 - 1000倍），这意味着炎症期间的清除率要高得多，且涉及一个明显不饱和的过程。除了高甘油三酯血症和丹吉尔病外，普通急性炎症现在也可被添加到导致apo A-I半衰期显著缩短的病理状况中。
