[花椒树皮乙酸乙酯提取物的化学成分研究]

[Study on chemical constituents of Zanthoxyli cortex's ethyl acetate extract].

作者信息

Liu Yan-qun, Yang Sheng-hui, Liu Qiang, Pei Gang, Pan Wei-wei, Liu Min, Peng Cai-yun

出版信息

Zhong Yao Cai. 2013 Nov;36(11):1792-5.

PMID:24956821

Abstract

OBJECTIVE

To study the chemical constituents of Zanthoxyli Cortex.

METHODS

The chemical constituents were isolated and purified by silica gel and HP-20, MCI gel, Sephadex LH -20 column chromatography, RP-18 and PTLC. Their structures were elucidated by the analysis of spectral data and chemical properties.

RESULTS

Ten compounds were isolated from EtOAc extract and their structures were identified as: asarinin (I), fargesin (II), eudesmin (III), (1R, 2R, 5R, 6S)-2-(3,4-dimethoxyphenyl)-6-(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3.3.0]-octane(IV), dimethoxysamin(V), rel-(1R,5R,6S)-6-(3,4-dimethoxyphen-yl)-3,7-dioxabicyclo-[3.3.0]-octan-2-one(VI), Magnone A(VII), beta-sitoste-rol( VIII), beta-armyrin(IX), beta-amyrone(X).

CONCLUSION

These compounds isolated from Zanthoxyli Cortex's Ethyl acetate extract are all known compounds. Fargesin(II) and beta-amyrone(X) are isolated from Zanthoxyli Cortex for the first time.

摘要

目的

研究黄柏的化学成分。

方法

采用硅胶柱色谱、HP - 20、MCI凝胶柱色谱、Sephadex LH - 20柱色谱、RP - 18柱色谱及制备薄层层析等方法对化学成分进行分离纯化，并通过光谱数据分析和化学性质鉴定其结构。

结果

从乙酸乙酯提取物中分离得到10个化合物，其结构分别鉴定为：细辛脂素（I）、大叶茜草素（II）、桉叶素（III）、(1R, 2R, 5R, 6S)-2-(3,4-二甲氧基苯基)-6-(3,4-二羟基苯基)-3,7-二氧杂双环[3.3.0]辛烷（IV）、二甲氧基胺（V）、rel-(1R,5R,6S)-6-(3,4-二甲氧基苯基)-3,7-二氧杂双环[3.3.0]辛烷-2-酮（VI）、Magnone A（VII）、β-谷甾醇（VIII）、β-香树脂醇（IX）、β-香树脂酮（X）。