Jacsó Olga, Fok Eva, Kiss Gabriella, Kökény Gábor, Lang Zsolt
Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent István University, István u. 2 H-1078 Budapest, Hungary.
Acta Vet Hung. 2010 Dec;58(4):405-12. doi: 10.1556/AVet.58.2010.4.1.
Subcutaneous dirofilariosis caused by Dirofilaria repens is common in dogs and it is an emerging helminthozoonosis in Europe, Asia, Africa and also in Hungary. Macrocyclic lactones are used for preventing the infection; however, their activity against the microfilariae and mature stages of this species is questionable. Selamectin is widely used for the prophylaxis of heartworm (D. immitis) infection. The objective of the present study was to test the microfilaricidal efficacy of the topical formulation of selamectin in dogs naturally infected with D. repens . A total of 78 Beagle dogs were examined for the presence of circulating microfilariae by Knott's test. Twenty-three of the microfilaraemic dogs were divided into four groups and included in the trial. The dogs received monthly or biweekly selamectin treatment and were subjected to monthly blood testing for a period of 252 or 336 days. At the end of the study, 65% of the dogs were not microfilaraemic and the rest had low number of microfilariae in their blood. These results indicate that chronic spot-on selamectin treatment may be a useful tool also in the control of canine subcutaneous dirofilariosis.
由匐行恶丝虫引起的犬皮下恶丝虫病在犬类中很常见，并且在欧洲、亚洲、非洲以及匈牙利都是一种新出现的人兽共患寄生虫病。大环内酯类药物用于预防感染；然而，它们对该物种微丝蚴和成虫阶段的活性存在疑问。塞拉菌素被广泛用于预防犬心丝虫（犬恶丝虫）感染。本研究的目的是测试塞拉菌素局部制剂对自然感染匐行恶丝虫的犬的杀微丝蚴效果。通过Knott氏试验对总共78只比格犬进行循环微丝蚴检测。23只血中带有微丝蚴的犬被分为四组并纳入试验。这些犬每月或每两周接受一次塞拉菌素治疗，并在252天或336天的时间内每月进行血液检测。在研究结束时，65%的犬血中无微丝蚴，其余犬血中的微丝蚴数量较少。这些结果表明，长期外用塞拉菌素治疗也可能是控制犬皮下恶丝虫病的一种有用方法。
