Dipt. di Salute Animale, Università degli Studi di Parma, via del Taglio 10, 43100 Parma, Italy.
Vet Parasitol. 2010 May 11;169(3-4):347-51. doi: 10.1016/j.vetpar.2010.01.025. Epub 2010 Jan 25.
Canine heartworm disease is caused by infection with Dirofilaria immitis, a filarial nematode that resides in the pulmonary arteries and occasionally in the right heart chambers of infected dogs. Here the authors evaluated the effect of a combination of doxycycline (10 mg/kg/sid for 30 days) and ivermectin–pyrantel(6μg/kg [DOSAGE ERROR CORRECTED] of ivermectin+5mg/kg of pyrantel every 15 days for 180 days) on microfilariemia, antigenemia and parasite load at echocardiography in naturally infected dogs from an endemic region of Italy. Dogs were examined monthly for 6 months and followed-up 4 months later. One hundred percent of dogs became negative for circulating microfilariae by day 90, while 8/11 (72.7%) of dogs became antigen-negative by day 300. Of the 7 dogs that were positive for visualization of parasites at echocardiography, 6 (85.7%) became negative by day 300. Treatment was well-tolerated by all dogs. These results suggest that a combination of doxycycline and ivermectin is adulticide in dogs with D. immitis.
犬心丝虫病是由犬恶丝虫感染引起的，该寄生虫寄生于感染犬的肺动脉，偶尔也寄生于右心腔。在这里，作者评估了多西环素（10mg/kg/sid，连用 30 天）和伊维菌素-吡喹酮（每 15 天 6μg/kg [剂量错误更正]的伊维菌素+5mg/kg 的吡喹酮，连用 180 天）联合应用对意大利疫区自然感染犬微丝蚴血症、抗原血症和超声心动图寄生虫负荷的影响。犬在 6 个月内每月检查一次，并在 4 个月后进行随访。100%的犬在第 90 天对循环微丝蚴呈阴性，而 11 只犬中有 8 只（72.7%）在第 300 天抗原阴性。在超声心动图上可见寄生虫的 7 只犬中，有 6 只（85.7%）在第 300 天转为阴性。所有犬均能耐受该治疗方案。这些结果表明，多西环素和伊维菌素联合应用对犬恶丝虫具有成虫杀灭作用。
