Loza-Rubio Elizabeth, Rojas-Anaya Edith
Centro Nacional de Investigaciones en Microbiología Animal, INIFAP, Carretera México Toluca Km 15.5, Colonia Palo Alto, CP 05110, Mexico.
Acta Vet Hung. 2010 Dec;58(4):511-22. doi: 10.1556/AVet.58.2010.4.11.
Plants have been identified as promising expression systems for the commercial production of vaccines because of the possibility of introducing exogenous genes into them, which permits the development of a new generation of biological products called edible vaccines. The advantages of oral vaccines of this new type are that they induce mucosal, humoral, cellular and protective immunity, they are cheaper, easier to store, distribute and administer, they do not require cold chain management, and some species can be stored for long periods of time without any spoilage and may be administered as purified proteins. Owing to these benefits, plant-produced vaccines represent a valuable option for animal health. The aim of this paper is to present a review of plant-produced vaccines against viruses affecting domestic animals. Some aspects of the feasibility of their use and the immune response elicited by such vaccines are also discussed, as the balance between tolerance and immunogenicity is a major concern for the use of plant-based vaccines.
由于有可能将外源基因导入植物，植物已被确定为用于商业生产疫苗的有前景的表达系统，这使得新一代被称为可食用疫苗的生物产品得以开发。这种新型口服疫苗的优点是它们能诱导黏膜、体液、细胞和保护性免疫，价格更便宜，更易于储存、分发和给药，不需要冷链管理，而且某些品种可以长时间储存而不会变质，还可以作为纯化蛋白给药。由于这些优点，植物生产的疫苗是动物健康的一个有价值的选择。本文的目的是综述针对影响家畜的病毒的植物生产疫苗。还讨论了其使用的可行性以及此类疫苗引发的免疫反应的一些方面，因为耐受性和免疫原性之间的平衡是使用植物源疫苗的一个主要关注点。
