Elmardi A S, Katchburian M V, Katchburian E
Department of Anatomy and Histology, London Hospital Medical College, England, UK.
Calcif Tissue Int. 1990 Apr;46(4):239-45. doi: 10.1007/BF02555002.
It is generally accepted that osteoclasts are responsible for the breakdown and removal of bone matrix constituents. However, very little is known about the fate of osteocytes during bone resorption. In the present study we have examined sites of bone destruction in calvaria of young rats aged 4-9 days in the hope of obtaining information on the fate of osteocytes. Decalcified glutaraldehyde-formaldehyde-fixed specimens were prepared for ultrathin section electron microscopy. When sequentially arranged, the images obtained suggest that osteoclasts engulf and destroy osteocytes during bone degradation. We propose that the following sequence of events takes place when a lacuna is opened up by an osteoclast: (1) When the osteoclast comes in contact with an osteocyte, the villi of the ruffled border become flat and broad. (2) Long osteoclastic extensions surround the osteocyte. (3) The osteocyte is subsequently internalized with apparent degradation.
一般认为破骨细胞负责骨基质成分的分解和清除。然而，关于骨吸收过程中骨细胞的命运却知之甚少。在本研究中，我们检查了4 - 9日龄幼鼠颅骨的骨破坏部位，以期获得有关骨细胞命运的信息。制备了脱钙的戊二醛 - 甲醛固定标本用于超薄切片电子显微镜检查。当按顺序排列时，所获得的图像表明破骨细胞在骨降解过程中吞噬并破坏骨细胞。我们提出当破骨细胞打开一个骨陷窝时会发生以下一系列事件：（1）当破骨细胞与骨细胞接触时，皱褶缘的微绒毛变平变宽。（2）长的破骨细胞突起围绕骨细胞。（3）随后骨细胞被内化并明显降解。
