Hoch Benjamin L, Garcia Roberto A, Smalberger Gert J
Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA.
Int J Surg Pathol. 2011 Apr;19(2):180-7. doi: 10.1177/1066896910381899. Epub 2010 Nov 17.
Tenosynovial giant cell tumor (TGCT) arises from the synovium of joints or tendon sheaths. Chondroid metaplasia in TGCT is rare with only 4 well-documented cases reported in the literature. The authors describe the morphological features and immunophenotype of 5 new cases of chondroid TGCT emphasizing a broader range of matrix patterns in these tumors and an expanded immunophenotype, specifically, staining for clusterin and podoplanin which have recently been found to be expressed in conventional TGCTs. Chondroid metaplasia was extensive in 3 cases. Matrix patterns included chondromyxoid, chondro-osseous, hyaline-like, and lace-like calcification similar to that seen in chondroblastoma. The authors conclude that chondroid TGCT is a rare, distinct synovial tumor with a predilection for the temporomandibular joint that has a similar immunophenotype as conventional TGCT. Chondroid metaplasia may be extensive and have a variety of matrix patterns. Chondroid TGCT needs to be distinguished from other chondroid lesions, including chondroblastoma and chondrosarcoma.
腱鞘巨细胞瘤（TGCT）起源于关节或腱鞘的滑膜。TGCT中的软骨化生很少见，文献中仅报道了4例有充分记录的病例。作者描述了5例新的软骨样TGCT病例的形态学特征和免疫表型，强调这些肿瘤中更广泛的基质模式和扩展的免疫表型，特别是，最近发现clusterin和podoplanin在传统TGCT中表达，故对其进行染色。3例病例中软骨化生广泛。基质模式包括软骨黏液样、软骨骨样、透明样和类似于成软骨细胞瘤中所见的花边样钙化。作者得出结论，软骨样TGCT是一种罕见的、独特的滑膜肿瘤，好发于颞下颌关节，其免疫表型与传统TGCT相似。软骨化生可能广泛且具有多种基质模式。软骨样TGCT需要与其他软骨样病变相鉴别，包括成软骨细胞瘤和软骨肉瘤。
