希腊一家大学医院分离的肺炎克雷伯菌的耐药状况及演变趋势：碳青霉烯类药物无效和对黏菌素的耐药性不断增加。
Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin.
机构信息
Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Greece.
出版信息
Chemotherapy. 2010;56(6):448-52. doi: 10.1159/000320943. Epub 2010 Nov 18.
BACKGROUND
Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens.
METHODS
The level of resistance to 25 antimicrobials of K. pneumoniae isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined.
RESULTS
A statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides >50% and to quinolones >60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin.
CONCLUSION
The effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep.
背景
由于其耐药率不断增加，肺炎克雷伯菌已成为最具问题的病原体之一。
方法
研究了来自希腊一所教学医院的肺炎克雷伯菌分离株对 25 种抗菌药物的耐药水平以及 20 年来的演变趋势。
结果
几乎所有检测的抗菌药物的耐药率均呈统计学显著增加。2008 年，分离株对氨基糖苷类药物的耐药率>50%，对喹诺酮类药物的耐药率>60%。如今，每 10 株分离株中就有 1 株对黏菌素耐药。此外，2007 年（29%）和 2008 年（50%）之间，对亚胺培南耐药的分离株几乎翻了一番。在亚胺培南耐药的分离株中，每 4 株就有 1 株对黏菌素也耐药。
结论
碳青霉烯类药物的疗效受到了影响，而对黏菌素的耐药性迅速而陡峭地增加。
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